ABSTRACT
Fungal infection is an important clinical problem for patients with immune deficiency or immunosuppression. With deadly fungus infection case increasing, the development of antifungal vaccine attracts the attention of researchers. Dendritic cell (DC) is the unique antigen presenting cell (APC) to trigger the antifungal immune reaction, and recent studies indicate that the targeted vaccination strategy based on DC have prospective antifungal potentials. In this paper, we review the antifungal immunity mechanism and recent development of the targeted DC antifungal strategy.
Subject(s)
Humans , Dendritic Cells , Fungal Vaccines , Therapeutic Uses , Mycoses , Allergy and Immunology , TherapeuticsABSTRACT
More than 20 protein bands with molecular weights of 19—175 KD in 18 strains of Ureaplosma urealyticum were detected by SDS-PAGE and thin layer scanning analysis. The molecular weights of major proteins were between 32 KD and 140 KD. Among them, the percentages of 67, 78 and 140 KD proteins were similar in all strains, but those of 32, 43 and 94 KD proteins were greatly different. Thus, Ureaplasma urealyticum can be divided into two groups: group A including serovars 2,5,7,9,10,11,12, and local isolates C,D, E, F; group B including serovars 1,3,6,13,14, and local isolates A, B. The serovars of Ureaplasma urealyticum could not be distinguished by using SDS-PAGE alone.